Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissues01:18

Tissues

Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
Tissue Membranes01:27

Tissue Membranes

A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
Connective Tissue Membranes
The connective tissue membrane is formed solely from connective tissue. These membranes encapsulate organs, such as the kidneys, and line our movable joints. A synovial membrane is...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum to PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells.

Cancer biology & medicine·2026
Same author

Interfacial microenvironment engineering in CO<sub>2</sub> electroreduction: mechanisms, advances, and perspectives.

Chemical communications (Cambridge, England)·2026
Same author

Balanced electrochemical reaction kinetics and mass transfer for stable zinc negative electrode.

Nature communications·2026
Same author

Novel models for predicting individualized outcomes in patients with advanced hepatocellular carcinoma receiving immunotherapy.

Frontiers in oncology·2026
Same author

Ethylene (Co)Polymerization Catalyzed by α‑Diimine Nickel Catalysts Bearing Ether Substituents.

Polymer science & technology (Washington, D.C.)·2026
Same author

Molten Salt Assisted Carbon Nitride Overcomes Inherent Photocatalytic Limitations: Unique Characteristics for High-Efficiency Light-Driven Energy Production.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
See all related articles

Related Experiment Video

Updated: May 13, 2026

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

8.4K

Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex.

Ao Chen1, Yidi Sun2, Ying Lei3

  • 1BGI-Shenzhen, Shenzhen 518103, China; Department of Biology, University of Copenhagen, Copenhagen 2200, Denmark; BGI Research-Southwest, BGI, Chongqing 401329, China; JFL-BGI STOmics Center, Jinfeng Laboratory, Chongqing 401329, China.

Cell
|July 13, 2023
PubMed
Summary
This summary is machine-generated.

Researchers mapped 264 cell types across the macaque cerebral cortex using advanced sequencing. This brain atlas reveals cell distribution linked to brain hierarchy and identifies primate-specific cell types, aiding future neuroscience research.

Keywords:
cell-type organizationhierarchymacaque cortexsingle-cellspatial transcriptome

More Related Videos

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing
06:38

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing

Published on: October 12, 2018

18.9K
Single-cell RNA Sequencing of Fluorescently Labeled Mouse Neurons Using Manual Sorting and Double In Vitro Transcription with Absolute Counts Sequencing DIVA-Seq
07:49

Single-cell RNA Sequencing of Fluorescently Labeled Mouse Neurons Using Manual Sorting and Double In Vitro Transcription with Absolute Counts Sequencing DIVA-Seq

Published on: October 26, 2018

9.5K

Related Experiment Videos

Last Updated: May 13, 2026

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

8.4K
Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing
06:38

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing

Published on: October 12, 2018

18.9K
Single-cell RNA Sequencing of Fluorescently Labeled Mouse Neurons Using Manual Sorting and Double In Vitro Transcription with Absolute Counts Sequencing DIVA-Seq
07:49

Single-cell RNA Sequencing of Fluorescently Labeled Mouse Neurons Using Manual Sorting and Double In Vitro Transcription with Absolute Counts Sequencing DIVA-Seq

Published on: October 26, 2018

9.5K

Area of Science:

  • Neuroscience
  • Genomics
  • Cell Biology

Background:

  • Understanding the cerebral cortex's cellular organization is key to brain function.
  • Previous studies lacked a comprehensive map of cell types and their spatial distribution.

Purpose of the Study:

  • To create a detailed atlas of macaque cortical cell types and their spatial organization.
  • To investigate the relationship between cell distribution, cortical hierarchy, and primate-specific cell types.

Main Methods:

  • Large-scale single-nucleus RNA sequencing.
  • Spatial transcriptomic analysis across 143 macaque cortical regions.
  • Cross-species transcriptomic comparison (human, macaque, mouse).

Main Results:

  • Comprehensive atlas of 264 transcriptome-defined cortical cell types.
  • Mapped spatial distribution of cell types across the macaque cortex.
  • Discovered links between cell distribution, regional hierarchy, and primate-specific cell types enriched in layer 4.

Conclusions:

  • Provides a cellular and molecular foundation for primate brain evolution, development, and disease.
  • Highlights the importance of spatial organization in cortical function.
  • Identifies novel primate-specific cell types with region-dependent gene expression.