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A perspective on In vitro developmental neurotoxicity test assay results: An expert panel review
D R Juberg1, D A Fox2, P A Forcelli3
1Juberg Toxicology Consulting LLC, Indianapolis, IN, USA.
Regulatory Toxicology and Pharmacology : RTP
|July 13, 2023
Summary
The DNT in vitro test battery (DNT IVB) shows promise for initial screening of chemical developmental neurotoxicity (DNT). However, it is not yet a complete replacement for in vivo testing to assess human DNT risks.
Area of Science:
- Toxicology
- Neuroscience
- Regulatory Science
Background:
- Growing concerns regarding chemical developmental neurotoxicity (DNT) have historically relied on in vivo testing.
- New Approach Methodologies (NAMs), including the DNT in vitro test battery (DNT IVB), have emerged to enhance screening, reduce animal use, and improve cost-efficiency.
Conclusions:
- The DNT IVB, in its current state, cannot fully capture the complexities of the developing nervous system.
- Further data generation and validation are essential before the DNT IVB can be integrated into global regulatory frameworks for chemical safety decisions.
