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Related Experiment Video

Updated: Jul 23, 2025

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Targeted therapy in glomerular diseases.

Yi-Chan Lin1, Tyng-Shiuan Gau2, Zheng-Hong Jiang2

  • 1Renal Division, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|July 13, 2023
PubMed
Summary

Targeted therapies offer a precise way to treat glomerular diseases by addressing specific disease mechanisms. This personalized approach, focusing on B-cells and complement pathways, represents the future of kidney disease treatment.

Keywords:
Complement activationIgA nephropathyImmune-mediated glomerular diseaseMembranous nephropathyTargeted therapy

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Area of Science:

  • Nephrology
  • Immunology
  • Pharmacology

Background:

  • Glomerular diseases are complex, often immune-mediated conditions requiring advanced treatment strategies.
  • Traditional immunosuppressive therapies have limitations, necessitating more personalized and targeted approaches.
  • Understanding specific pathogenic mechanisms is key to developing effective treatments.

Purpose of the Study:

  • To review the evolving understanding of pathogenic mechanisms in immune-mediated glomerular diseases.
  • To summarize the development of targeted therapies based on these mechanisms.
  • To highlight the potential of personalized medicine in treating glomerular diseases.

Main Methods:

  • Review of current literature on pathogenic mechanisms in glomerular diseases.
  • Analysis of targeted therapies including B-cell depletion (rituximab, anti-CD38) and complement pathway inhibition.
  • Examination of clinical trials investigating targeted treatments for various glomerular diseases and kidney fibrosis.

Main Results:

  • Targeted therapies focus on specific molecular pathways like B-cell signaling (BAFF/APRIL) and complement activation (terminal, lectin, alternative pathways).
  • These therapies are being developed for conditions such as IgA nephropathy, lupus nephritis, C3 glomerulopathy, and ANCA-associated vasculitis.
  • Clinical trials are underway to assess targeted treatments for glomerular diseases and associated kidney fibrosis.

Conclusions:

  • Targeted therapies represent a paradigm shift in managing glomerular diseases, moving towards personalized treatment strategies.
  • Individualized therapeutic approaches based on specific pathogenic mechanisms are crucial for future advancements.
  • Further research and clinical trials are essential to optimize targeted therapies for glomerular diseases.