Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Factors affecting tissue aluminum concentration.

G H Mayor, J A Keiser, T V Sanchez

    Journal of Dialysis
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The effects of aluminum loading on selected tissue calcium and magnesium concentrations in rats.

    Biological trace element research·2013
    Same author

    In vivo and in vitro effects of aluminum treatment on rat liver mitochondrial function.

    Biological trace element research·2013
    Same author

    Evaluation of cinacalcet HCl treatment after kidney transplantation.

    Transplantation proceedings·2010
    Same author

    Lanthanum carbonate vs. sevelamer hydrochloride for the reduction of serum phosphorus in hemodialysis patients: a crossover study.

    Clinical nephrology·2009
    Same author

    Beta2-microglobulin stimulates osteoclast formation.

    Kidney international·2008
    Same author

    Mortality risk among hemodialysis patients receiving different vitamin D analogs.

    Kidney international·2007
    Same journal

    Protein binding of bilirubin in plasma of anephric patients.

    Journal of dialysis·1980
    Same journal

    Treatment of uremic pericardial effusion by local steroid instillation via subxiphoid pericardiotomy.

    Journal of dialysis·1980
    Same journal

    Antidiuretic hormone in end-stage renal disease.

    Journal of dialysis·1980
    Same journal

    Peritoneal dialysis in the treatment of severe hypercalcemia.

    Journal of dialysis·1980
    Same journal

    Axillary graft-subclavian venous extension for salvage of graft arteriovenous fistulae.

    Journal of dialysis·1980
    Same journal

    Acute flank pain in dialysed patients. Demonstration of hydronephrosis by computer tomography.

    Journal of dialysis·1980
    See all related articles

    Aluminum accumulation in patients with kidney disease is linked to neurotoxicity, particularly in dialysis patients. Parathyroid hormone may influence aluminum levels, explaining why some patients develop neurological issues while others do not.

    Area of Science:

    • Nephrology
    • Neuroscience
    • Toxicology

    Background:

    • Elevated aluminum levels are observed in patients with renal insufficiency.
    • Aluminum is strongly implicated as a neurotoxin in the dialysis population.
    • The exact sources of aluminum exposure (gastrointestinal, parenteral) remain unclear.

    Purpose of the Study:

    • To investigate the role of aluminum in dialysis encephalopathy.
    • To explore potential factors influencing aluminum toxicity in patients with kidney disease.
    • To examine the effect of parathyroid hormone on tissue aluminum burdens.

    Main Methods:

    • Analysis of aluminum concentrations in serum, whole blood, and tissue samples.
    • Review of clinical data from dialysis and non-dialysis patients.

    Related Experiment Videos

  • Laboratory investigations into parathyroid hormone's effect on aluminum accumulation.

    • Main Results:

    • Data suggest parathyroid hormone influences tissue aluminum burdens.
    • This effect may explain differential susceptibility to dialysis encephalopathy.
    • Dialysis encephalopathy can occur even without dialysis or high dialysate aluminum.

    Conclusions:

    • Parathyroid hormone plays a role in modulating aluminum toxicity in renal patients.
    • Understanding these mechanisms is crucial for managing neurological complications in kidney disease.
    • Further research is needed to fully elucidate aluminum's neurotoxic pathways.