Full-field stimulus threshold testing: a scoping review of current practice

Area of Science:

• Ophthalmology
• Psychophysics
• Clinical Trials

Background:

• Full-field stimulus threshold (FST) measures whole-field retinal light sensitivity.
• FST assesses visual function in severe retinal disease and is used in clinical trials.
• Growing use in clinics lacks standardized guidance for FST measurement.

Purpose of the Study:

• To explore variability in FST conduct and reporting.
• To inform evidence synthesis and consensus guidance for FST.
• To identify needs for standardized FST methodology.

Main Methods:

• Scoping review following PRISMA-ScR guidelines.
• Comprehensive literature search and data extraction from 85 sources.
• Qualitative and quantitative comparison of FST methodology and outcomes.

Main Results:

• Significant variability exists in FST methodology (luminance, color, duration, test strategy, dark adaptation).
• Insufficient reporting hinders cross-center comparison and interpretation of clinical significance.
• An unmet need for pediatric-specific FST considerations was identified.

Conclusions:

• Standardized guidance for FST methodology is required.
• Consistent reporting of core elements, like flash luminance equivalence, is a crucial first step.
• Quality assurance, calibration, and age-appropriate reference data are needed to strengthen FST rigor.