Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

357
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
357
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

298
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
298
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

222
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
222
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

489
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
489
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

143
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
143
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

175
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
175

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined acetaldehyde metabolism burden modifies IBD susceptibility to alcohol consumption.

Gut·2026
Same author

Biologics and small molecules for perianal Crohn's disease: a systematic review and meta-analyses of randomized placebo-controlled trials.

Inflammatory bowel diseases·2026
Same author

Fecal ACE and ACE2 Activities Reflect Intestinal Shedding and Microbiota Modulation of Renin-Angiotensin System.

Biology·2026
Same author

Time to rethink washout periods in inflammatory bowel disease clinical trials: an international Delphi consensus.

Journal of Crohn's & colitis·2026
Same author

Precision nutrition for the prevention and management of inflammatory bowel disease.

Nature reviews. Gastroenterology & hepatology·2026
Same author

Soluble transferrin receptor as a reliable inflammation-independent marker of iron deficiency in Crohn's disease and ulcerative colitis.

Inflammatory bowel diseases·2026

Related Experiment Video

Updated: Jul 23, 2025

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
10:21

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Published on: September 12, 2019

7.2K

How to Evaluate Fibrosis in IBD?

Helena Tavares de Sousa1,2, Fernando Magro3,4,5

  • 1Gastroenterology Department, Algarve University Hospital Center, 8500-338 Portimão, Portugal.

Diagnostics (Basel, Switzerland)
|July 14, 2023
PubMed
Summary

Fibrosis significantly impacts inflammatory bowel disease (IBD), affecting Crohn's disease (CD) and ulcerative colitis (UC) differently. While noninvasive methods show promise, surgical pathology remains the gold standard for diagnosing intestinal fibrosis.

Keywords:
biomarkersfibrosisimaginginflammationinflammatory bowel disease

More Related Videos

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.2K
Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

67.4K

Related Experiment Videos

Last Updated: Jul 23, 2025

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
10:21

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Published on: September 12, 2019

7.2K
Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.2K
Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

67.4K

Area of Science:

  • Gastroenterology
  • Pathology
  • Medical Imaging

Background:

  • Fibrosis is a critical complication in inflammatory bowel disease (IBD), with distinct manifestations in Crohn's disease (CD) and ulcerative colitis (UC).
  • Understanding the interplay between inflammation and fibrosis, including inflammation-independent fibrogenesis, is crucial for disease management.
  • Accurate assessment of intestinal fibrosis is essential for effective treatment strategies in IBD.

Purpose of the Study:

  • To review the significance of fibrosis in IBD, differentiating its impact on CD and UC.
  • To explore the correlation between inflammation and fibrosis, and the mechanisms of inflammation-independent fibrogenesis.
  • To discuss recent advancements in noninvasive assessment of intestinal fibrosis, including imaging and biomarkers.

Main Methods:

  • Review of existing literature on IBD fibrosis, inflammation-fibrosis correlation, and fibrogenesis.
  • Analysis of current noninvasive assessment techniques: cross-sectional imaging (CSI), magnetic resonance elastography (MRE), elastography, radiomics, and biomarkers (micro-RNAs).
  • Comparison of the diagnostic accuracy and limitations of various noninvasive methods against surgical pathology.

Main Results:

  • No current CSI technique accurately measures CD fibrosis; MRE and elastography show potential.
  • Radiomics demonstrates encouraging preliminary results for fibrosis assessment, requiring further validation with reliable biomarkers.
  • Micro-RNA research is promising, but robust clinical trials with validated endpoints are needed for fibrosis biomarker development.

Conclusions:

  • Noninvasive assessment of intestinal fibrosis in IBD is evolving, with radiomics and artificial intelligence (AI) poised to play a future role in CSI.
  • Despite advancements, surgical pathology remains the definitive method for diagnosing and quantifying intestinal fibrosis in IBD.
  • Further research and validated clinical trials are necessary to establish reliable noninvasive biomarkers and imaging techniques for IBD fibrosis.