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Pathogens like viruses and bacteria can form a biomolecular corona in the bloodstream, similar to nanoparticles. This "blood interactome" may explain individual differences in disease susceptibility and offers a new therapeutic target.

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Area of Science:

  • Biomedical science
  • Immunology
  • Nanotechnology

Background:

  • Artificial nanoparticles acquire a biomolecular corona in biological fluids.
  • Pathogens are biological entities with nanometric dimensions.

Purpose of the Study:

  • To propose that pathogens also acquire a biomolecular corona upon entering circulation.
  • To conceptualize this corona as part of a broader non-cellular blood interactome.
  • To explore the potential of the blood interactome as a therapeutic target.

Main Methods:

  • Review of published data on nanoparticle biomolecular coronas.
  • Generalization of these concepts to viruses and bacteria.
  • Conceptual framework development for the non-cellular blood interactome.

Main Results:

  • Pathogens may form a specific biomolecular corona in blood.
  • This corona is a component of the organism-specific non-cellular blood interactome.
  • The interactome may be analogous to innate immune responses.

Conclusions:

  • The non-cellular blood interactome, including pathogen coronas, can influence individual susceptibility to infections.
  • Characterizing the blood interactome may reveal mechanisms of disease.
  • The non-cellular blood interactome presents a potential therapeutic target for various conditions.