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Updated: Jul 23, 2025

Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy

Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy

Published on: June 27, 2013

Atomic Force Microscopy Methods to Measure Tumor Mechanical Properties.

Julian Najera¹, Matthew R Rosenberger¹, Meenal Datta¹

¹Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.

|July 14, 2023

Summary

This summary is machine-generated.

Atomic force microscopy (AFM) offers high-resolution insights into the mechanical properties of biological tissues. This review explores AFM

Keywords:

Young’s modulus cancer mechanopathology mechanobiomarkers nanomechanical signatures stiffness viscoelasticity

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Last Updated: Jul 23, 2025

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Area of Science:

Biophysics
Cancer Research
Materials Science

Background:

Atomic force microscopy (AFM) is crucial for evaluating biological material mechanical properties.
Cancer researchers utilize AFM to link mechanobiology with cancer initiation, progression, and treatment resistance.
Previous AFM studies primarily focused on cell nanomechanics, neglecting tumor and host organ complexity.

Purpose of the Study:

To review the principles and applications of AFM nanoindentation for tissue mechanics.
To highlight key considerations for using AFM in tissue analysis.
To examine AFM's role in characterizing cancer tissue mechanics and its clinical potential.

Main Methods:

Explains AFM nanoindentation principles for tissue mechanics.
Discusses critical considerations for AFM technique application and tissue sample preparation.
Reviews AFM applications in cancer tissue mechanical property characterization.

Main Results:

AFM enables high-resolution evaluation of biological material mechanical properties.
Characterizing tissue-scale mechanics provides novel insights into cancer mechanopathology.
AFM applications are expanding beyond cellular to tissue-level cancer research.

Conclusions:

AFM is a valuable tool for understanding cancer mechanobiology at the tissue scale.
Further research using AFM can bridge the gap between mechanobiology and clinical cancer applications.
AFM holds promise for future clinical diagnostics and treatment strategies in oncology.