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Updated: Jun 17, 2026
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
Analysis of the Peritumoral Tissue Unveils Cellular Changes Associated with a High Risk of Recurrence
Audrey Michot1,2,3, Pauline Lagarde2,3, Tom Lesluyes2
1Bordeaux Institute of Oncology, BRIC U1312, INSERM, 33000 Bordeaux, France.
Background:
The management of soft-tissue sarcoma (STS) relies on a multidisciplinary approach involving specialized oncological surgery combined with other adjuvant therapies to achieve optimal local disease control. Purpose and Results: Genomic and transcriptomic pseudocapsules of 20 prospective sarcomas were analyzed and revealed to be correlated with a higher risk of recurrence after surgery.
Conclusions:
A peritumoral environment that has been remodeled and infiltrated by M2 macrophages, and is less expressive of healthy tissue, would pose a significant risk of relapse and require more aggressive treatment strategies.
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