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Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

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Related Experiment Video

Updated: Jun 23, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
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'Stealth' Prostate Tumors.

Vinayak G Wagaskar1, Osama Zaytoun1,2, Swati Bhardwaj3

  • 1Department of Urology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.

Cancers
|July 14, 2023
PubMed
Summary
This summary is machine-generated.

Prebiopsy magnetic resonance imaging (MRI) and systematic prostate biopsy (PBx) have significant false negative rates for prostate cancer (PCa) detection. Improved diagnostic strategies are needed to enhance accuracy and tumor localization.

Keywords:
magnetic resonance imagingprostate biopsyprostate cancer

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Area of Science:

  • Urology
  • Oncology
  • Radiology

Background:

  • Prostate cancer (PCa) diagnosis relies on prebiopsy imaging and biopsies.
  • False negative results can lead to delayed or missed diagnoses.

Purpose of the Study:

  • To determine the false negative rates of prebiopsy MRI and MRI-ultrasound (US) guided 12-core systematic prostate biopsy (PBx).
  • To analyze radical prostatectomy specimens to assess diagnostic accuracy.

Main Methods:

  • Retrospective analysis of 3600 prostate cancer patients undergoing robot-assisted radical prostatectomy.
  • Patients were categorized based on biopsy and MRI findings: contralateral benign PBx, non-suspicious mpMRI, or both.
  • Evaluated for PCa, clinically significant PCa (csPCa), extracapsular extension (ECE), and positive surgical margins (PSM).

Main Results:

  • PCa detection rates varied across subgroups (19.5%–37.7%), with csPCa rates ranging from 10.3%–16.3%.
  • Contralateral pT3 disease and positive surgical margins were observed in 4-7% of cases across subgroups.

Conclusions:

  • Standard diagnostic methods for PCa exhibit significant false negative rates.
  • Further strategies are essential to improve diagnostic accuracy and precise tumor localization.