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Function in Cancer Patients: Disease and Clinical Determinants.

Evelyn S Qin1, Blair Richards2, Sean R Smith3

  • 1Department of Rehabilitation Medicine, University of Washington, Seattle, WA 98195, USA.

Cancers
|July 14, 2023
PubMed
Summary

Cancer type and disease status significantly impact physical function and social participation. Specific cancers like brain, sarcoma, prostate, and lymphoma are linked to lower function during active disease.

Keywords:
PROMISPROMIS Cancer Function Brief 3D Profilecancercancer functioncancer rehabilitationcancer typefunctional outcomesimpairmentsphysical function

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Area of Science:

  • Oncology
  • Rehabilitation Medicine
  • Patient-Reported Outcomes

Background:

  • Cancer patients frequently experience functional changes during and post-treatment.
  • Identifying cancer types and clinical factors influencing function is crucial for targeted rehabilitation.

Purpose of the Study:

  • To evaluate patient-reported functional impairments across specific cancer types.
  • To identify risk factors associated with disease status and non-cancer factors affecting function.

Main Methods:

  • Cross-sectional study of 332 individuals referred to cancer rehabilitation clinics.
  • Utilized the PROMIS Cancer Function Brief 3D Profile to assess physical function, fatigue, and social participation.
  • Employed multivariable modeling to analyze interactions between cancer type, cancer status, and functional outcomes.

Main Results:

  • An interaction between cancer type and status affected physical function and social participation.
  • Active cancer status was linked to lower physical function and social participation in brain, sarcoma, prostate, and lymphoma.
  • Premorbid impairments predicted lower function in non-active cancer patients; cancer type did not impact function in those with no evidence of disease.
  • Fatigue was associated with younger age, higher BMI, premorbid musculoskeletal impairment, and active cancer status, independent of cancer type.

Conclusions:

  • Cancer type and active disease status are key determinants of physical function and social participation.
  • Premorbid conditions are significant predictors of functional decline in non-active cancer patients.
  • Anticipatory guidance on common impairments can enhance cancer rehabilitation care and support patients and caregivers.