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Biomarkers Associated with Thrombosis in Patients with Peripherally Inserted Central Catheter: A Systematic Review

Patrícia Cristina Cardoso1, Eneida Rejane Rabelo-Silva1,2,3, Patricia Martins Bock4

  • 1Graduate Program in Cardiology and Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil.

Journal of Clinical Medicine
|July 14, 2023
PubMed

Insights

High D-dimer and platelet levels indicate a risk for deep vein thrombosis (DVT) in patients with peripherally inserted central catheters (PICCs). Other tested biomarkers were not associated with PICC-related DVT.

Area of Science:

  • Biomedical research
  • Clinical diagnostics
  • Vascular medicine

Background:

  • Plasma biomarkers aid in estimating risk and diagnosing deep vein thrombosis (DVT).
  • Peripherally inserted central catheters (PICCs) are associated with DVT risk.
  • Identifying reliable biomarkers for PICC-related DVT is crucial for patient management.

Purpose of the Study:

  • To systematically review and meta-analyze the association between various biomarkers and PICC-related DVT.
  • To identify biomarkers reflecting blood system activation, vascular complications, and inflammation in PICC-DVT.
  • To determine the diagnostic or prognostic value of these biomarkers.

Main Methods:

  • Systematic literature search of seven electronic databases up to December 2022.
  • Inclusion of studies comparing patients with and without PICC-related DVT reporting biomarker levels.
  • Quality assessment using Newcastle-Ottawa Scale and meta-analysis of findings.

Main Results:

  • Twenty-eight studies were included in the analysis.
  • Elevated D-dimer levels were significantly associated with PICC-related DVT (p=0.04).
  • Increased platelet counts were also linked to PICC-related DVT (p=0.02).

Conclusions:

  • High D-dimer and platelet levels are associated with DVT in patients with PICCs.
  • Biomarkers including APTT, fibrinogen, FDP, glucose, hemoglobin, HbA1c, INR, PT, PF1.2, TAT, and WBC were not found to be related to PICC-DVT development.
  • Further research may refine the role of D-dimer and platelets in PICC-DVT risk stratification.
Abstract

Keywords:
catheterizationperipheralsystematic reviewthrombosis

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