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Multisensory Stimulation Reverses Memory Impairment in Adrβ3KO Male Mice
Thaís T Ravache1, Alice Batistuzzo1, Gabriela G Nunes1
1Programa de Pós-Graduação em Distúrbios do Desenvolvimento, Centro de Ciências Biológicas e da Saúde Universidade Presbiteriana Mackenzie, São Paulo 01302-907, SP, Brazil.
International Journal of Molecular Sciences
|July 14, 2023
Summary
Multisensory stimulation (MS) reversed memory deficits in young mice lacking beta-3 adrenergic receptors (Adrβ3KO) by reducing neuroinflammation. However, MS was ineffective in older Adrβ3KO mice, indicating age-related memory impairment.
Area of Science:
- Neuroscience
- Neuropharmacology
- Behavioral Neuroscience
Background:
- Norepinephrine modulates memory via beta-adrenergic receptors (Adrβ), including Adrβ3.
- Beta-3 adrenergic receptor (Adrβ3) inactivation impairs memory and may involve neuroinflammation.
Purpose of the Study:
- To investigate if multisensory stimulation (MS) can reverse memory impairment in Adrβ3 knockout (Adrβ3KO) mice.
- To determine if MS-induced reversal of memory deficits is mediated by reduced glial-mediated inflammation.
Main Methods:
- 21- and 86-day-old Adrβ3KO mice underwent an 8-week multisensory stimulation (MS) protocol.
- MS included diverse sensory, cognitive, and foraging challenges.
- Hippocampal and amygdalar protein expression (GFAP, Iba-1, EAAT2) was analyzed.
Main Results:
- MS reduced neuroinflammation markers (GFAP, Iba-1) in young Adrβ3KO mice's hippocampus.
- MS restored memory function in young Adrβ3KO mice treated post-weaning.
- MS failed to improve memory or reduce neuroinflammation in older Adrβ3KO mice.
Conclusions:
- Early-life environmental enrichment (MS) can correct memory deficits in Adrβ3KO mice by mitigating neuroinflammation.
- Aging exacerbates memory impairment in Adrβ3KO mice, rendering MS ineffective in adulthood.
- Targeting neuroinflammation early may be crucial for preventing age-related memory decline.
