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Published on: April 4, 2018
Microfluidics and Organoids, the Power Couple of Developmental Biology and Oncology Studies
Laura Ann Hetzel1, Ahmed Ali1, Vincenzo Corbo2
1Leiden Academic Center for Drug Research, Leiden University, 2333 CC Leiden, The Netherlands.
Abstract:
Organoids are an advanced cell model that hold the key to unlocking a deeper understanding of in vivo cellular processes. This model can be used in understanding organ development, disease progression, and treatment efficacy. As the scientific world embraces the model, it must also establish the best practices for cultivating organoids and utilizing them to the greatest potential in assays. Microfluidic devices are emerging as a solution to overcome the challenges of organoids and adapt assays. Unfortunately, the various applications of organoids often depend on specific features in a device. In this review, we discuss the options and considerations for features and materials depending on the application and development of the organoid.
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