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Exploring the Interplay between Polyphenols and Lysyl Oxidase Enzymes for Maintaining Extracellular Matrix
Carolina Añazco1, Janin Riedelsberger2, Lorenzo Vega-Montoto3
1Laboratorio de Bioquímica Nutricional, Escuela de Nutrición y Dietética, Carrera de Nutrición y Dietética, Facultad de Ciencias para el Cuidado de la Salud, Universidad San Sebastián, General Lagos #1190, Valdivia 5110773, Chile.
International Journal of Molecular Sciences
|July 14, 2023
Summary
Plant polyphenols can inhibit collagen glycation and mimic lysyl oxidase activity. This review explores how these compounds stabilize collagen fibrils by modulating cross-linking processes.
Area of Science:
- Biochemistry
- Molecular Biology
- Extracellular Matrix Research
Background:
- Collagen fibrils are strengthened by covalent cross-links, essential for tissue integrity.
- Lysyl oxidase (LOX) enzyme initiates cross-linking by deaminating lysine residues.
- Non-enzymatic glycation forms Advanced Glycation End-products (AGEs), altering collagen properties.
Purpose of the Study:
- To review plant polyphenols with amine oxidase-like activity and antiglycation properties.
- To explore the molecular mechanisms of flavonoid action on collagen cross-linking.
- To discuss harnessing these dual activities for collagen stabilization.
Main Methods:
- Literature review of studies on polyphenols, LOX activity, and glycation.
- Analysis of molecular mechanisms of flavonoid interactions with collagen.
- Compilation of evidence for polyphenol-mediated collagen cross-linking modulation.
Main Results:
- Plant polyphenols exhibit amine oxidase-like activity and inhibit protein glycation.
- Specific flavonoids impact collagen cross-linking pathways.
- Polyphenols can protect against AGE formation and promote proper cross-linking.
Conclusions:
- Polyphenols possess dual activities beneficial for collagen health.
- These compounds offer potential therapeutic strategies for stabilizing collagen fibrils.
- Harnessing polyphenol properties can lead to improved collagen structure and function.
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