Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Central nervous system-penetrant anti-C1q therapy reduces neuroinflammation and preserves neurological function in a model of progressive multiple sclerosis.

Brain, behavior, and immunity·2026
Same author

Stable Undifferentiated Connective Tissue Disease and CNS Demyelination: A Case Report and a Literature Review.

Case reports in neurological medicine·2025
Same author

Network analysis of intrathecally synthesized proteins to unravel mechanisms of disease course in multiple sclerosis.

Journal of neuroimmunology·2025
Same author

The CXCL13 index biomarker predicts success or failure of moderate-efficacy disease-modifying therapies in multiple sclerosis; A real-world study.

Multiple sclerosis and related disorders·2025
Same author

CXCL13 as a Biomarker: Background and Utility in Multiple Sclerosis.

Biomolecules·2025
Same author

CXCL10/IgG1 Axis in Multiple Sclerosis as a Potential Predictive Biomarker of Disease Activity.

Neurology(R) neuroimmunology & neuroinflammation·2024

Related Experiment Video

Updated: Jul 23, 2025

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling
10:03

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling

Published on: December 12, 2014

8.2K

The CXCL13 Index as a Predictive Biomarker for Activity in Clinically Isolated Syndrome.

Steven C Pike1,2,3, Francesca Gilli1,2, Andrew R Pachner1

  • 1Department of Neurology, Geisel School of Medicine at Dartmouth and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.

International Journal of Molecular Sciences
|July 14, 2023
PubMed
Summary

The CXCL13 index (ICXCL13) can predict multiple sclerosis (MS) progression. High ICXCL13 levels in early MS stages indicate a higher likelihood of developing definite MS.

Keywords:
B cellCXCL13clinically isolated syndromeinitial clinical demyelinating eventmultiple sclerosisradiologically isolated syndrome biomarker

More Related Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

491
Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

23.8K

Related Experiment Videos

Last Updated: Jul 23, 2025

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling
10:03

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling

Published on: December 12, 2014

8.2K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

491
Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

23.8K

Area of Science:

  • Neuroimmunology
  • Biomarker Discovery
  • Clinical Neurology

Background:

  • Multiple sclerosis (MS) is a complex neurological disease with variable clinical presentations.
  • Accurate prediction of disease activity is crucial for timely therapeutic interventions.
  • Current methods lack sufficient precision in identifying patients who will experience rapid disease progression.

Purpose of the Study:

  • To evaluate the CXCL13 index (ICXCL13) as a predictive biomarker for future disease activity in early MS.
  • To assess the long-term predictive value of ICXCL13 in patients with clinically isolated syndrome (CIS) or radiologically isolated syndrome (RIS).

Main Methods:

  • Patients with CIS or RIS underwent lumbar puncture and blood draw for ICXCL13 determination.
  • Intrathecal production of CXCL13 was measured to calculate the ICXCL13.
  • Participants were followed for at least 5 years to monitor MS activity and conversion to clinically definite MS.

Main Results:

  • Patients with high ICXCL13 showed a significantly higher conversion rate to clinically definite MS (82.4%) compared to those with low ICXCL13 (10.0%).
  • The predictive accuracy of ICXCL13 was confirmed over a minimum 5-year follow-up period, extending previous 2-year findings.
  • This predictive capability was consistent in both CIS and RIS patient cohorts.

Conclusions:

  • The CXCL13 index (ICXCL13) serves as a robust biomarker for predicting long-term disease activity in early MS.
  • ICXCL13 has the potential to guide the selection of patients who may benefit from early immunomodulatory therapy.
  • This biomarker could personalize treatment strategies in multiple sclerosis management.