Antipyrine kinetics following influenza vaccination

To test the hypothesis that hepatic drug metabolism affected the pharmacokinetics of antipyrine, 12 persons who had received vaccination against influenza were given antipyrine on the fourth day following. Plasma antipyrine was assayed from venous blood samples taken 5, 11 and 24 h later. The results indicate that the immunization procedure transiently increased the hepatic drug metabolizing enzyme activity against antipyrine.