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Stem/Progenitor Cells and Related Therapy in Bronchopulmonary Dysplasia

Manuela Marega1,2, Natalia El-Merhie3, Mira Y Gökyildirim4

  • 1German Center for Lung Research (DZL), Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Justus Liebig University Giessen, 35392 Giessen, Germany.

International Journal of Molecular Sciences
|July 14, 2023
PubMed

Insights

Mesenchymal stem cells (MSCs) show promise for treating bronchopulmonary dysplasia (BPD) in infants by reducing inflammation and promoting lung repair. Further research is needed to standardize MSC therapies and evaluate potential side effects for clinical use.

Area of Science:

  • Neonatal Medicine
  • Regenerative Medicine
  • Pulmonology

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease in preterm infants, leading to long-term respiratory and developmental issues.
  • Current treatments for BPD offer limited therapeutic benefits and can have significant side effects.
  • Mesenchymal stem cells (MSCs) are being investigated for their potential anti-inflammatory and regenerative properties in lung injury.

Purpose of the Study:

  • To review the characteristics and differentiation potential of lung stem/progenitor cells, including MSCs.
  • To summarize preclinical and clinical evidence for stem cell-based therapies in BPD.
  • To identify gaps in knowledge and future research directions for MSC-based treatments.

Main Methods:

  • Review of existing literature on MSCs and other lung stem cells.
  • Analysis of preclinical animal studies investigating stem cell efficacy in lung injury models.
  • Examination of clinical trial data on stem cell or secretome therapies for BPD.

Main Results:

  • MSCs exhibit anti-inflammatory effects and secrete factors that promote lung repair.
  • Preclinical studies suggest MSCs can ameliorate lung injury.
  • Clinical trials are emerging, but data is still limited.

Conclusions:

  • MSCs represent a promising therapeutic avenue for BPD, offering potential for lung repair.
  • Standardized protocols and critical evaluation of side effects are necessary for clinical translation.
  • Further preclinical and clinical studies are required to fully elucidate MSC behavior and secretome effects in BPD.

Keywords:
bronchopulmonary dysplasiachronic lung diseaseextracellular vesiclesinflammationlung injurypremature infantsstem cellstissue repair

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