Editorial for the Special Issue "Biological and Toxicological Studies of Nanoparticles"

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Whole-Body Nanoparticle Aerosol Inhalation Exposures
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Olivier Joubert1

  • 1Institut Jean Lamour, CNRS 7198, University of Lorraine, 54015 Nancy, France.

Nanomaterials (Basel, Switzerland)
|July 14, 2023
PubMed

Abstract:

Nanoparticles have attracted a great deal of attention over the past two decades or more due to their unique size-dependent physical and chemical properties [...].

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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