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Connexin 43 Phosphorylation: Implications in Multiple Diseases.

Meng Zhang1, Zhen-Zhen Wang1, Nai-Hong Chen1

  • 1State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.

Molecules (Basel, Switzerland)
|July 14, 2023
PubMed
Summary
This summary is machine-generated.

Connexin 43 (Cx43) phosphorylation impacts gap junction function and intercellular communication. Understanding Cx43 phosphorylation is key for developing therapeutic strategies in cardiovascular and neurological diseases.

Keywords:
connexin 43intercellular communicationphosphorylationthe cardiovascular systemthe nervous system

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Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Physiology

Background:

  • Connexin 43 (Cx43) is abundant in mammalian cardiovascular and nervous systems.
  • Cx43 phosphorylation is regulated by multiple kinases and phosphatases, influencing its function.
  • Phosphorylation affects Cx43 synthesis, assembly, and gap junction (GJ) properties.

Purpose of the Study:

  • To review the functional significance of Cx43 phosphorylation in various diseases.
  • To discuss Cx43 as a potential drug target for Cx43-related pathophysiology.
  • To highlight Cx43's role in cardiac and neuroprotection.

Main Methods:

  • Literature review of clinical and preclinical findings.
  • Analysis of Cx43 phosphorylation's impact on GJ function.
  • Exploration of Cx43 as a therapeutic target.

Main Results:

  • Cx43 phosphorylation modulates GJ permeability, electrical conductivity, and gating.
  • Altered Cx43 phosphorylation affects intercellular communication in physiological and pathological conditions.
  • Cx43 phosphorylation plays a role in diverse disease processes.

Conclusions:

  • Clarifying Cx43 phosphorylation-disease relationships enhances disease understanding.
  • Cx43 represents a promising therapeutic target for cardiovascular and neurological conditions.
  • Targeting Cx43 phosphorylation offers potential for cardiac and neuroprotection strategies.