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Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications

Mateusz Kciuk1,2, Manzar Alam3, Nemat Ali4

  • 1Department of Molecular Biotechnology and Genetics, University of Lodz, Banacha Street 12/16, 90-237 Lodz, Poland.

Molecules (Basel, Switzerland)
|July 14, 2023
PubMed

Insights

Epigallocatechin-3-gallate (EGCG), a green tea compound, regulates key cancer-related cell signaling pathways. EGCG shows potential for cancer prevention and treatment by influencing cell proliferation and apoptosis.

Area of Science:

  • * Molecular Biology
  • * Oncology
  • * Pharmacology

Background:

  • * Cancer pathogenesis involves dysregulated cellular signaling pathways controlling cell proliferation and apoptosis.
  • * Epigallocatechin-3-gallate (EGCG), a major green tea polyphenol, modulates numerous critical signaling pathways.
  • * These pathways include those mediated by EGFR, JAK-STAT, MAPKs, NF-κB, and PI3K-AKT-mTOR.

Purpose of the Study:

  • * To review the biological properties of EGCG.
  • * To explore EGCG's role in cancer treatment and prevention.
  • * To summarize current knowledge on EGCG's effects on cancer-related signaling.

Main Methods:

  • * Literature review of preclinical and clinical studies.
  • * Analysis of EGCG's impact on cellular signaling pathways.
  • * Examination of EGCG's anti-cancer effects.

Main Results:

  • * EGCG demonstrates anti-proliferative, anti-inflammatory, and apoptosis-inducing effects.
  • * EGCG can induce epigenetic modifications.
  • * EGCG influences multiple cancer-associated signaling cascades.

Conclusions:

  • * EGCG exhibits significant potential as a therapeutic agent for cancer.
  • * EGCG may serve as a valuable tool for cancer prophylaxis.
  • * Further research into EGCG's mechanisms and clinical applications is warranted.
Keywords:
bioavailabilityclinical trialsepigallocatechin gallatesignaling pathways

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