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Updated: Jul 23, 2025

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
Published on: April 23, 2019
Human Olfactory Receptor Sensor for Odor Reconstitution.
Shun'ichi Kuroda1,2, Yukiko Nakaya-Kishi2, Kenji Tatematsu1,2
1Department of Biomolecular Science and Reaction, SANKEN, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
Digital transformation (DX) of human senses is advancing, but olfactory DX remains challenging due to the complexity of odor molecules. This review explores the potential of human olfactory DX using advanced odor sensors.
Area of Science:
- Biotechnology
- Sensory Science
- Digital Transformation
Background:
- Human senses like sight, sound, and touch are physical phenomena easily digitized.
- Taste and smell, being chemical phenomena, lack objective digital data representation.
- Digital transformation (DX) has been achieved for most senses except smell and taste.
Purpose of the Study:
- To review the current status and future prospects of human olfactory DX.
- To address the challenges in digitizing the vast range of odor molecules.
- To propose a novel approach for olfactory DX using human olfactory receptors.
Main Methods:
- Discussion of existing challenges in olfactory data digitization.
- Exploration of odor sensors utilizing human olfactory receptors (ORs).
- Analysis of the potential of OR-based sensors for DX.
Main Results:
- Olfactory DX is significantly more complex than other sensory DX due to the sheer number of odor molecules.
- Human olfactory receptors (ORs) offer a promising biological basis for developing accurate odor sensors.
- OR-based sensors could enable the conversion of complex odors into digital data.
Conclusions:
- Human olfactory DX is achievable through the development of advanced odor sensors.
- Utilizing human olfactory receptors in sensors is a key strategy for olfactory DX.
- This approach holds the potential to revolutionize how we record, transmit, and replay olfactory information.
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