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Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

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Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
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Murine Fetal Echocardiography
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Routine first-trimester pre-eclampsia screening and maternal left ventricular geometry.

A Ridder1,2, J O'Driscoll3,4, A Khalil1,2

  • 1Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, University of London, London, UK.

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
|July 14, 2023
PubMed
Summary
This summary is machine-generated.

First-trimester screening for preterm pre-eclampsia (PE) identified individuals with abnormal left ventricular (LV) geometry. This early cardiac remodeling may indicate future cardiovascular disease risk in clinically healthy pregnant individuals.

Keywords:
cardiac hypertrophycardiovascular pregnancy complicationsechocardiographyfirst-trimester pregnancyleft ventricular hypertrophyleft ventricular remodelingpre-eclampsiauteroplacental circulation

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Area of Science:

  • Cardiovascular physiology in pregnancy
  • Maternal-fetal medicine
  • Diagnostic imaging in obstetrics

Background:

  • Pre-eclampsia (PE) is linked to premature cardiovascular disease.
  • Adverse left ventricular (LV) remodeling occurs during pregnancy and is a risk factor for cardiovascular disease.
  • Early identification of PE risk is crucial for managing maternal cardiovascular health.

Purpose of the Study:

  • To compare LV geometry, specifically LV mass (LVM) and LVM index (LVMI), between high-risk and low-risk groups for preterm PE in the first trimester.
  • To investigate potential early indicators of cardiovascular risk in pregnancy.

Main Methods:

  • Prospective cohort study of singleton pregnancies (11–14 weeks gestation).
  • Preterm PE screening using the Fetal Medicine Foundation algorithm.
  • Echocardiography to assess LV mass and LVMI.
  • High-risk group: ≥1 in 50 risk; Low-risk group: ≤1 in 500 risk.

Main Results:

  • 128 participants analyzed; 71 high-risk, 57 low-risk.
  • High-risk group had higher BMI, arterial blood pressure, and heart rate.
  • Significantly higher median LVM and mean LVMI in the high-risk group (P < 0.001).
  • Abnormal LV geometry was more prevalent in the high-risk group (37.1% vs 7.0%, P < 0.001).

Conclusions:

  • Early echocardiographic screening in high-risk preterm PE pregnancies can identify individuals with abnormal LV geometry.
  • This finding suggests increased susceptibility to future cardiovascular disease.
  • Adverse cardiac remodeling in early pregnancy may signal reduced cardiovascular reserve.