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[Determination of prolactin reference intervals in different age groups].

G S Kolesnikova1, N M Malysheva1, Z T Zuraeva1

  • 1Endocrinology Research Center.

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|July 14, 2023
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Summary

This study establishes new reference values for prolactin testing using the VITROS ECi 3600 system in the Russian population. The findings reveal a systematic shift in expected prolactin levels compared to manufacturer recommendations.

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Area of Science:

  • Endocrinology
  • Clinical Chemistry
  • Laboratory Medicine

Context:

  • Automated diagnostic systems present challenges in standardizing biochemical marker measurements, such as prolactin.
  • Discrepancies between patient clinical presentation and manufacturer-provided reference values necessitate population-specific data.
  • Variability in prolactin levels, even with proper blood sampling, complicates interpretation.

Purpose:

  • To determine serum prolactin reference values for various age groups using the VITROS Immunodiagnostic Systems.
  • To compare these determined values with the manufacturer's expected prolactin levels for the VITROS ECi 3600 analyzer.
  • To establish method-specific reference values for the Russian population.

Summary:

  • Reference values for adult men and women were determined as 66-436 mIU/l and 94-500 mIU/l, respectively.
  • A systematic increase in both lower and upper limits of reference values was observed compared to the manufacturer's expected values.
  • The study utilized 879 serum samples from apparently healthy individuals at the Endocrinology Research Center.

Impact:

  • Provides crucial, population-specific reference ranges for prolactin assays performed on the VITROS ECi 3600 system.
  • Aids endocrinologists in more accurate prolactin level interpretation within the Russian population.
  • Highlights the importance of method-specific and population-specific reference values in clinical diagnostics.