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Updated: Jul 23, 2025
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A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
Published on: October 24, 2018
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Deciphering the Metabolome under Stress: Insights from Rodent Models
Maria P Papageorgiou1,2, Daniela Theodoridou3, Markus Nussbaumer1,2
1Laboratory of Biochemistry, Department of Biological Applications and Technology, School of Health Sciences, University of Ioannina, Greece.
Current Neuropharmacology
|July 14, 2023
Summary
Metabolomics reveals molecular signatures of psychological stress in rodent models. This approach offers insights into stress-induced systemic changes in the brain and peripheral tissues.
Area of Science:
- Neuroscience
- Molecular Biology
- Biochemistry
Background:
- Psychological stress impacts health, but its molecular mechanisms are not fully understood.
- Rodent models are crucial for studying stress responses.
- Metabolomics offers a holistic view of stress-induced molecular alterations.
Approach:
- This review covers rodent stress models (mice, rats) and metabolomics techniques like mass spectrometry (MS) and nuclear magnetic resonance (NMR).
- Focus on acute, chronic, and early life stress paradigms.
- Analysis of metabolomic data from brain and peripheral samples (plasma, serum).
Key Points:
- Metabolomics quantifies small molecule changes in response to stress.
- Identifies stress-specific molecular signatures in biological samples.
- Behavioral and molecular stress assessments are integrated.
Conclusions:
- Metabolomics provides valuable insights into the complex pathobiology of stress.
- Common metabolomic patterns emerge across different stress models.
- Unbiased -omics and follow-up studies are needed to fully understand stress and related psychopathologies.
