Related Experiment Video

Updated: Jul 23, 2025

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence

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Managing Patent Foramen Ovale (PFO) in Adults With Cryptogenic Stroke and Lymphoma: A Multidisciplinary Perspective

Noman Khalid1, Muhammad Abdullah2, Sacide S Ozgur1

  • 1Internal Medicine, St. Joseph's Regional Medical Center, Paterson, USA.

Cureus
|July 14, 2023
PubMed

Insights

Patent foramen ovale (PFO) can cause cryptogenic strokes. Closing a PFO may be an option for stroke patients, but requires careful consideration by a multidisciplinary team.

Area of Science:

  • Neurology
  • Cardiology
  • Oncology

Background:

  • Cryptogenic strokes lack a clear cause, with patent foramen ovale (PFO) being a suspected etiology.
  • PFO closure is a potential intervention for cryptogenic stroke management.
  • A middle-aged male with lymphoma experienced a stroke secondary to an undiagnosed PFO.

Observation:

  • The patient presented with altered mental status, indicative of a stroke.
  • Diagnostic workup revealed an underlying patent foramen ovale as the cause of the stroke.
  • The patient had a concurrent diagnosis of lymphoma.

Findings:

  • The case highlights the complexity of managing cryptogenic strokes in patients with comorbidities.
  • Decision-making regarding PFO closure requires a thorough evaluation of individual risk factors.
  • The stroke was attributed to an underlying PFO in a patient with lymphoma.

Implications:

  • This case underscores the importance of a multidisciplinary team approach in evaluating cryptogenic stroke patients.
  • Factors influencing the decision for PFO closure, especially in complex cases, need careful consideration.
  • Optimal patient management necessitates a comprehensive assessment integrating neurological, cardiac, and oncological perspectives.

Keywords:
bubble studycryptogenic strokelymphomaparadoxical embolipatent foramen ovale

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