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Updated: Jul 23, 2025

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
The Anterior Cruciate Ligament: Principles of Treatment
Prannoy Shom1, Anuj R Varma2, Roshan Prasad3
1Orthopaedics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Abstract:
The anterior cruciate ligament (ACL) is a crucial connective tissue in the knee joint (tibiofemoral joint). Although the surgical anatomy of this ligament has been studied and interpreted for decades, it remains a topic of discussion among surgeons. The ACL has two bundles, the anteromedial (AM) and the posterolateral (PL) bundle. ACL tears are among the most frequently sustained injuries to the tibiofemoral joint. The ACL is an important rotational stabilizer of the knee joint. The human knee joint can be classified as a complex structure, as it has many ligaments supporting its stability and ensuring required joint mobility. Previously, the outcomes of primary ACL surgery were poor; however, with time, the modalities have improved substantially. There are two methods of performing the reconstruction procedure, the single-bundle method, in which only the AM bundle is reconstructed, and the double-bundle method, in which both the AM and PL bundles of the ACL are reconstructed. Double bundle arthroscopic ACL reconstruction has been recognized as the gold standard procedure. The grafts used for the reconstruction procedure are the tendon of the patella graft and the grafts of the hamstrings. However, one of the drawbacks of performing this surgery is the development of complications, like osteoarthritis. This complication is observed majorly in sports professionals. This article aims to sum up the anatomy of the ACL, its regular tears, the various surgical aspects of managing it, and the advancement of treatment options in the past centuries. Although much has been achieved, detailed scientific studies should be carried out to improve the prognosis and decrease the risk of development of complications.
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