Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis
Xinyi Yang1, Huimin Wu1, Yu Song1
1Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Background:
Mild cognitive impairment (MCI) depicts a transitory phase between healthy elderly and the onset of Alzheimer's disease (AD) with worsening cognitive impairment. Some functional MRI (fMRI) research indicated that the frontoparietal network (FPN) could be an essential part of the pathophysiological mechanism of MCI. However, damaged FPN regions were not consistently reported, especially their interactions with other brain networks. We assessed the fMRI-specific anomalies of the FPN in MCI by analyzing brain regions with functional alterations.
Methods:
PubMed, Embase, and Web of Science were searched to screen neuroimaging studies exploring brain function alterations in the FPN in MCI using fMRI-related indexes, including the amplitude of low-frequency fluctuation, regional homogeneity, and functional connectivity. We integrated distinctive coordinates by activating likelihood estimation, visualizing abnormal functional regions, and concluding functional alterations of the FPN.
Results:
We selected 29 studies and found specific changes in some brain regions of the FPN. These included the bilateral dorsolateral prefrontal cortex, insula, precuneus cortex, anterior cingulate cortex, inferior parietal lobule, middle temporal gyrus, superior frontal gyrus, and parahippocampal gyrus. Any abnormal alterations in these regions depicted interactions between the FPN and other networks.
Conclusion:
The study demonstrates specific fMRI neuroimaging alterations in brain regions of the FPN in MCI patients. This could provide a new perspective on identifying early-stage patients with targeted treatment programs.
Systematic Review Registration:
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432042, identifier: CRD42023432042.
Insights
Functional MRI (fMRI) reveals specific brain alterations in the frontoparietal network (FPN) of patients with mild cognitive impairment (MCI). These findings aid in identifying early-stage MCI for targeted interventions.
Area of Science:
- Neuroimaging
- Cognitive Neuroscience
- Neurology
Background:
- Mild cognitive impairment (MCI) represents a transitional stage between normal aging and Alzheimer's disease.
- The frontoparietal network (FPN) is implicated in MCI pathophysiology, but specific affected regions and network interactions remain unclear.
- Functional magnetic resonance imaging (fMRI) is crucial for investigating brain function alterations in MCI.
Approach:
- A systematic review and meta-analysis of neuroimaging studies using fMRI.
- Searched PubMed, Embase, and Web of Science for studies on FPN alterations in MCI.
- Utilized activation likelihood estimation to integrate and visualize abnormal functional regions.
Key Points:
- Identified specific FPN regions with altered function in MCI: bilateral dorsolateral prefrontal cortex, insula, precuneus cortex, anterior cingulate cortex, inferior parietal lobule, middle temporal gyrus, superior frontal gyrus, and parahippocampal gyrus.
- Observed that alterations in these regions indicate interactions between the FPN and other brain networks.
- Synthesized findings from 29 selected studies.
Conclusions:
- This study pinpoints distinct fMRI-based neuroimaging anomalies within the FPN in individuals with MCI.
- These identified alterations offer a potential biomarker for early MCI detection.
- Provides a foundation for developing targeted therapeutic strategies for early-stage MCI patients.
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