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Coronavirus disease 2019 and acute cerebrovascular events: a comprehensive overview

Wanzhou Zhang1,2, Li Ling1, Jie Li1

  • 1Department of Neurology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.

Frontiers in Neurology
|July 14, 2023
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, causing COVID-19, is linked to cerebrovascular events. Potential mechanisms include hypercoagulability and inflammation, with ongoing research into treatments.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiovascular Medicine

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has seen a rise in acute cerebrovascular events.
  • Cerebrovascular complications include cerebral infarction, hemorrhage, and venous thrombosis in COVID-19 patients.

Purpose of the Study:

  • To explore the mechanisms linking SARS-CoV-2 infection to acute cerebrovascular events.
  • To review characteristics and treatment options for COVID-19-related cerebrovascular complications.

Main Methods:

  • Literature review and synthesis of existing research on SARS-CoV-2 and cerebrovascular events.
  • Analysis of proposed pathophysiological pathways, including hypercoagulability, inflammation, and renin-angiotensin-aldosterone system alterations.

Main Results:

  • SARS-CoV-2 infection is associated with increased risk of ischemic and hemorrhagic stroke.
  • Hypercoagulable state and excessive inflammation are implicated in COVID-19-related cerebrovascular events.
  • Alterations in the ACE-2 pathway may contribute to these complications.

Conclusions:

  • Understanding the mechanisms of SARS-CoV-2-induced cerebrovascular events is crucial for patient management.
  • Further research is needed to optimize treatment strategies for COVID-19 patients experiencing neurological complications.

Keywords:
COVID-19SARS-CoV-2hypercoagulabilityischemic strokemechanical thrombectomy

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