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Related Concept Videos

Fineness Modulus01:19

Fineness Modulus

The fineness modulus (FM) of aggregate is a numerical index that measures the coarseness or fineness of the particles. It is calculated by adding the cumulative percentages of aggregate retained on each of a specified series of sieves and dividing the sum by 100.
Consider performing sieve analysis on sand through a set of ASTM sieves. The weight of aggregate retained in each sieve and pan placed at the bottom is recorded, as given in Column B of Table 1.
To determine the fineness modulus of...

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Microparticles with tunable, cell-like properties for quantitative acoustic mechanophenotyping.

Ryan Dubay1,2, Eric M Darling1,3,4,5, Jason Fiering2

  • 1Center for Biomedical Engineering, Brown University, Providence, RI 02912 USA.

Microsystems & Nanoengineering
|July 14, 2023
PubMed
Summary

Researchers developed tunable microparticles to calibrate microfluidic devices for high-throughput cell mechanical property measurement. This innovation enables precise characterization of cell mechanics, aiding disease diagnosis and biological research.

Keywords:
EngineeringMaterials sciencePhysics

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Area of Science:

  • Biophysics
  • Biomaterials Science
  • Microfluidics

Background:

  • Cellular mechanical properties correlate with biomolecular state and function.
  • High-throughput methods for measuring cell mechanics are needed.
  • Existing calibration methods using microspheres lack tunable mechanical properties.

Purpose of the Study:

  • To develop novel, tunable microparticles for calibrating microfluidic devices.
  • To characterize an acoustic microfluidic device using these tunable particles.
  • To demonstrate the application of tunable particles for high-throughput cell analysis.

Main Methods:

  • Development of monodisperse polyacrylamide microparticles with tunable elasticity and density.
  • Characterization of a custom acoustic microfluidic device.
  • Application to measure acoustic properties of human leukocytes.

Main Results:

  • Successfully created microparticles with adjustable size, elasticity, and density.
  • Characterized an acoustic microfluidic device for single-cell mechanical property measurement.
  • Demonstrated discrimination of lymphocytes from other leukocytes based on acoustic properties.

Conclusions:

  • Tunable microparticles provide a precise calibration standard for microfluidic devices.
  • This approach enables efficient, high-throughput mechanical property measurements at single-cell resolution.
  • The technology has potential applications in cell biology and clinical diagnostics.