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Recent advances in permeable polymersomes: fabrication, responsiveness, and applications
Yanyan Zhu1, Shoupeng Cao2, Meng Huo3
1Department of Chemical Engineering, School of Environmental and Chemical Engineerin, Shanghai University Shanghai 200444 China hche@shu.edu.cn.
Chemical Science
|July 14, 2023
Summary
This review explores creating permeable polymersomes, stable nanostructures for drug delivery and nanomedicine. Strategies discussed balance robustness with controlled permeability for advanced applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Polymer Chemistry
Background:
- Polymersomes are stable nanostructures from block copolymers, surpassing liposomes in robustness.
- Applications include drug delivery, nanomedicine, and artificial cells.
- High molecular weight polymersomes exhibit limited permeability, posing a challenge.
Purpose of the Study:
- To review strategies for fabricating permeable polymersomes.
- To highlight applications of these advanced nanostructures.
- To address challenges in developing polymersomes for biomedical use.
Main Methods:
- Discussing polymersomes with intrinsic permeability.
- Detailing nanopore formation via protein insertion.
- Exploring stimuli-responsive polymersome construction.
Main Results:
- Permeable polymersomes offer enhanced functionality over conventional ones.
- Various fabrication methods allow tuning of permeability.
- Successful applications demonstrated in nanoreactors and nanomedicine.
Conclusions:
- Balancing polymersome robustness and permeability is achievable through innovative design.
- Permeable polymersomes show significant promise for biomedical applications.
- Further development is needed to overcome current challenges in soft matter engineering.
