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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
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Long-term effects of primary hyperparathyroidism and parathyroidectomy on kidney function
Catherine Y Zhu1, Hui X Zhou2,3, Chi-Hong Tseng4
1Section of Endocrine Surgery, Department of Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, United States.
European Journal of Endocrinology
|July 14, 2023
Summary
In primary hyperparathyroidism (PHPT), accelerated kidney function decline (eGFR) occurs with high calcium levels. Parathyroidectomy can mitigate this decline in affected patients.
Area of Science:
- Endocrinology
- Nephrology
- Surgical Research
Background:
- Primary hyperparathyroidism (PHPT) is a condition with limited evidence regarding kidney dysfunction as an indication for parathyroidectomy.
- Understanding the natural history of kidney function in PHPT is crucial.
Purpose of the Study:
- To investigate the progression of kidney function in patients with PHPT.
- To determine if parathyroidectomy impacts renal outcomes in PHPT patients.
Main Methods:
- A matched control study involving 6058 PHPT subjects and 16,388 controls from 2000-2016.
- Analysis of estimated glomerular filtration rate (eGFR) trajectories over 10 years, stratified by hypercalcemia severity.
- Interrupted time series analysis comparing eGFR in PHPT patients with and without parathyroidectomy.
Main Results:
- Accelerated eGFR decline was observed in PHPT patients with serum calcium >2.87 mmol/L (11.5 mg/dL), affecting 16% of cases.
- The rate of eGFR decline was significantly higher in these patients compared to controls.
- Parathyroidectomy mitigated eGFR decline in patients with serum calcium >2.87 mmol/L.
Conclusions:
- A minority of PHPT patients with elevated serum calcium (>2.87 mmol/L) experience accelerated kidney function decline.
- Parathyroidectomy demonstrates a potential benefit in mitigating this decline, suggesting its consideration in managing renal outcomes for these patients.
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