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Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices.

Durva Naik1, Gaurav Balakrishnan1, Mahathy Rajagopalan2

  • 1Materials Science and Engineering Department, Carnegie Mellon University, 5000 Forbes Avenue, Wean Hall, 3325, Pittsburgh, PA, 15213, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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Summary
This summary is machine-generated.

This study introduces a novel intestinal retentive device that mechanically interlocks with the small intestine's natural villi. This non-penetrative approach offers a promising strategy for sustained drug delivery and ingestible medical devices.

Keywords:
digital light processing (DLP) 3D printingintestinal retentionmechanical interlockingmicrostructuresreplica moldingvilli

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Area of Science:

  • Biomedical Engineering
  • Gastroenterology
  • Materials Science

Background:

  • Intestinal retentive devices are crucial for sustained oral drug delivery and indwelling medical applications.
  • Current retention methods rely on mucoadhesion or mechanical piercing, posing limitations.
  • A non-penetrative mechanical interlocking strategy is needed for safer and more effective intestinal retention.

Purpose of the Study:

  • To evaluate the feasibility of intestinal retention using villi-inspired micropost structures.
  • To investigate the mechanical interlocking between microposts and natural intestinal villi.
  • To predict optimal design parameters for in vivo retention of non-penetrative devices.

Main Methods:

  • Computational simulations to estimate resistance to peristaltic shear forces.
  • In vitro fabrication of micropost array patches using replica molding.
  • Lap-shear tests to assess interlocking performance with artificial villi.

Main Results:

  • Simulations provided insights into the viability of mechanical interlocking for intestinal retention.
  • Fabricated micropost patches demonstrated effective interlocking with artificial villi.
  • Optimal material and design parameters for in vivo retention were predicted.

Conclusions:

  • Micropost-villi mechanical interlocking is a viable strategy for intestinal retention.
  • This proof-of-concept study paves the way for non-penetrative, multifunctional intestinal devices.
  • The developed technology holds potential for advanced drug delivery and ingestible medical applications.