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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

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Stimuli-Responsive Delivery of Antimicrobial Peptides Using Polyelectrolyte Complexes.

Alexander Antropenko1,2,3, Frank Caruso3, Paco Fernandez-Trillo1,2,4

  • 1School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Macromolecular Bioscience
|July 14, 2023
PubMed
Summary

Stimuli-responsive polyelectrolyte complexes enhance antimicrobial peptide (AMP) stability and enable targeted delivery, overcoming challenges in clinical translation for combating antimicrobial resistance.

Keywords:
antimicrobial peptidesdrug deliverypolyelectrolyte complexesstimuli-responsive materials

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Antimicrobial Research

Background:

  • Antimicrobial peptides (AMPs) show promise against antimicrobial resistance but face clinical translation hurdles due to toxicity and instability.
  • Polyelectrolyte complexes offer a strategy to encapsulate AMPs, improving their stability and enabling controlled release.

Purpose of the Study:

  • To review stimuli-responsive polyelectrolyte complexes for enhanced AMP delivery.
  • To explore pH, enzyme, and temperature-responsive systems for targeted AMP release during infection.

Main Methods:

  • Overview of pH-responsive polyelectrolyte complexes for AMP delivery.
  • Discussion of other infection-associated stimuli (enzymes, temperature).
  • Analysis of dual stimuli-responsive systems (pH and temperature).

Main Results:

  • pH-responsive systems demonstrate potential for switchable surfaces and intracellular delivery.
  • Balancing AMP efficacy and stability remains a key challenge.
  • Dual stimuli-responsive systems offer advanced control over AMP release.

Conclusions:

  • Stimuli-responsive polyelectrolyte complexes can improve AMP stability and facilitate targeted delivery.
  • Further research is needed to overcome challenges and translate these systems for clinical use.
  • This approach holds significant potential for developing next-generation antimicrobials.