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Liquid Biopsy in Adverse Neurodevelopment of Children: Problems and Prospects
Yiwei Pu1, Jia An1, Xuming Mo2
1Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.
Insights
Early detection of neurodevelopmental disorders is crucial for lifelong quality of life. This review explores neurodevelopmental monitoring methods and the potential of liquid biopsy for early, personalized interventions.
Area of Science:
- Pediatric Neurology
- Developmental Biology
- Biomarker Discovery
Background:
- Neurodevelopmental disorders significantly impact lifelong quality of life, posing social and economic burdens.
- Early and middle childhood represents a critical window for neurodevelopmental assessment and intervention.
- Current monitoring tools often lack prenatal and early-stage assessment capabilities.
Conclusions:
- Early and accurate diagnosis of neurodevelopmental disorders is essential for improving patient outcomes.
- Liquid biopsy offers a non-invasive avenue for prenatal and early childhood neurodevelopmental monitoring.
- Advancements in biomarker identification through liquid biopsy can facilitate timely, individualized interventions.
Abstract:
Neurodevelopmental disorders in children have an important impact on the quality of life in the whole life cycle. Severe neurodevelopmental disorders will become a serious social and family burden and an important social and economic problem. The early and middle childhood is the critical period of children's neurodevelopment. Early diagnosis of neurological disorders plays an important role in guiding children's neurological development. Existing monitoring tools lack prenatal and even early assessment of children's neurodevelopment, so reliable biomarkers are conducive to personalized care at an earlier stage. In this review, we will discuss different methods of neurodevelopmental monitoring at different times and the role and evaluation of liquid biopsy in neurodevelopmental monitoring.
