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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

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Different sonographic presentations of dermatofibrosarcoma protuberans.

Carolina Whittle¹, A Andrews², G Coulon³

¹Department of Radiology, Facultad de Medicina, Clínica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile. cwhittlep@gmail.com.

Journal of Ultrasound

|July 14, 2023

Summary

Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer. Ultrasound reveals varied presentations, including nodules and ill-defined lesions, aiding in diagnosis and determining tumor extent for treatment planning.

Keywords:

Dermatofibrosarcoma Dermatology Doppler color ultrasound High resolution ultrasound Soft tissue sarcoma

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Area of Science:

Radiology
Oncology
Dermatology

Background:

Dermatofibrosarcoma protuberans (DFSP) is a low-grade spindle cell sarcoma of fibroblastic origin.
DFSP typically originates in the dermis and can infiltrate subcutaneous tissue.
It most commonly affects adults aged 30-40, often on the trunk and extremities.

Purpose of the Study:

To analyze the ultrasound and demographic findings in patients diagnosed with DFSP.
To identify characteristic ultrasound patterns associated with DFSP.
To evaluate the utility of ultrasound in determining the extent and depth of DFSP lesions.

Main Methods:

Retrospective analysis of ultrasound and demographic data from thirteen DFSP patients.
Detailed examination of lesion characteristics on ultrasonography, including echogenicity, borders, and tissue plane involvement.
Inclusion of color Doppler imaging findings.

Main Results:

Thirteen patients (8 female, 5 male) aged 2 months to 58 years were analyzed.
Ultrasonography showed dermal-hypodermal involvement in 93% of cases; aponeurotic plane involvement occurred in two cases.
Common ultrasound presentations included well-defined hypoechogenic nodules (50%), ill-defined hypoechogenic infiltrates (21%), plaques, and pseudonodular inflammatory lesions, all demonstrating vascularity on Doppler.

Conclusions:

DFSP is a low-grade sarcoma with variable clinical presentations.
Ultrasound reveals diverse patterns: nodules, infiltrates, plaques, and pseudonodular lesions.
Recognizing these suspicious ultrasound presentations is crucial for recommending timely histological examination.