Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Computed Tomography01:10

Computed Tomography

4.6K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.6K
Positron Emission Tomography01:29

Positron Emission Tomography

4.3K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.3K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

28
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
28
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

158
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
158

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<b>Special Volume of International Symposium of Tropical Fish Ecological Conservation and Biodiversity 2025 (ISTFECB 2025) Part I-Systematics, taxonomy, and species diversity of tropical fishes (Title page)</b>.

Zootaxa·2026
Same author

<b>Special Volume of International Symposium of Tropical Fish EcologicalConservation and Biodiversity 2025 (ISTFECB 2025) Part I-Systematics, taxonomy, and species diversity of tropical fishes (Table of contents)</b>.

Zootaxa·2026
Same author

<b>Preface: Special Volume of International Symposium of Tropical Fish Ecological Conservation and Biodiversity 2025 (ISTFECB 2025) Part I-Systematics, taxonomy, and species diversity of tropical fishes: contributed papers from ISTFECB 2025</b>.

Zootaxa·2026
Same author

<b>A new species of dwarf goby of <i>Trimma</i> (Teleostei: Gobiidae) from Taiping Island, South China Sea</b>.

Zootaxa·2026
Same author

<b>A new species of <i>Luciogobius</i> Gill (Teleostei: Gobiidae) from northern Taiwan</b>.

Zootaxa·2026
Same author

<b>A new wriggler of Eleotrid (Teleostei: Xenisthmidae) from Taiping Island, South China Sea</b>.

Zootaxa·2026

Related Experiment Video

Updated: Jul 23, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.4K

An optimized framework for cone-beam computed tomography-based online evaluation for proton therapy.

Chih-Wei Chang1, Rasmus Nilsson2, Sebastian Andersson2

  • 1Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.

Medical Physics
|July 14, 2023
PubMed
Summary

This study introduces an online cone-beam CT (CBCT) evaluation framework for proton therapy, enhancing efficiency and accuracy. The framework helps select optimal synthetic CT (sCT) methods for improved patient outcomes in adaptive radiotherapy.

Keywords:
CBCT-based evaluationonline adaptationproton therapy

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.8K
Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.4K

Related Experiment Videos

Last Updated: Jul 23, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.4K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.8K
Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.4K

Area of Science:

  • Medical Physics
  • Radiotherapy
  • Image-guided therapy

Background:

  • Proton therapy offers comparable tumor control to photon therapy with reduced healthy tissue toxicity.
  • Proton therapy's sensitivity to anatomical variations necessitates robust online evaluation.
  • Lack of established guidelines hinders the clinical implementation of online pre-fraction evaluation workflows.

Purpose of the Study:

  • To develop and evaluate a cone-beam CT (CBCT)-based online framework for proton therapy.
  • To ensure knowledge transparency and assess the efficiency and accuracy of key framework components.
  • To provide a foundation for implementing online adaptive radiotherapy workflows.

Main Methods:

  • A retrospective study involving 23 patients with diverse lesion sites.
  • Implementation of a CBCT evaluation framework on the RayStation 11B Research platform.
  • Comparison of two synthetic CT (sCT) methods (corrected CBCT and virtual CT) against same-day deformed quality assurance CT (dQACT).
  • Evaluation metrics included time efficiency, dose-difference distributions (gamma passing rates), and water-equivalent thickness (WET) distributions.

Main Results:

  • Mean online CBCT evaluation times were 1.6 ± 0.3 min (cCBCT) and 1.9 ± 0.4 min (vCT).
  • Dose calculation and deformable image registration were major time contributors (33% and 30%, respectively).
  • Gamma passing rates exceeded 91% (1%/1 mm) and 97% (2%/2 mm).
  • Mean WET differences were <0.5 mm with appropriate sCT selection.
  • Corrected CBCT (cCBCT) proved superior for head-and-neck, while virtual CT (vCT) was better for lung patients.

Conclusions:

  • An online CBCT evaluation framework was successfully developed, optimizing sCT selection for efficiency and accuracy.
  • The framework is adaptable for advanced imaging and supports online adaptive radiotherapy.
  • The proposed framework has potential for future clinical integration to improve patient benefits.