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Updated: Jul 23, 2025

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
BAG3: An enticing therapeutic target for idiopathic pulmonary fibrosis
Shashipavan Chillappagari1,2, Andreas Guenther1,2,3,4,5, Poornima Mahavadi1,2
1Department of Internal Medicine, Justus-Liebig University (JLU) Giessen, Giessen, Germany.
Abstract:
Idiopathic pulmonary fibrosis (IPF) is a dreadful and fatal disease of unknown etiology, for which no cure exists. Autophagy, a lysosomal cellular surveillance pathway is insufficiently activated in both alveolar epithelial type II cells and fibroblasts of IPF patient lungs. Fine-tuning this pathway may result in the degradation of the accumulated cargo and influence cell fate. Based on our previous data, we here present our view on modulating autophagy via a unique co-chaperone, namely Bcl2-associated athanogene3 (BAG3) in IPF and discuss about how repurposing drugs that modulate this pathway may emerge as a promising novel therapeutic approach for IPF.
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