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Related Experiment Videos

Depressive symptoms in propranolol users.

S J Griffin, M J Friedman

    The Journal of Clinical Psychiatry
    |September 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Propranolol treatment for cardiovascular illness was studied in 34 male patients. Higher depression scores were found in those with a history of depression, with a positive correlation between propranolol dosage and depression in this subgroup.

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    Area of Science:

    • Cardiovascular medicine
    • Psychiatry
    • Clinical pharmacology

    Background:

    • Propranolol is a beta-blocker commonly prescribed for cardiovascular conditions.
    • Depressive symptoms can be a side effect or comorbidity in patients with cardiovascular illness.
    • The relationship between propranolol use and depression requires further investigation, particularly in specific patient populations.

    Purpose of the Study:

    • To investigate the prevalence and correlation of depressive symptoms in white male patients undergoing propranolol treatment for cardiovascular illness.
    • To examine the influence of personal or family history of depression on depression scores.
    • To determine the relationship between propranolol dosage and depressive symptoms, considering patient history.

    Main Methods:

    Related Experiment Videos

  • A cohort of 34 white male patients receiving propranolol for cardiovascular illness was assessed.
  • Depressive symptoms were measured using the Hamilton Rating Scale for Depression and the Hudson Generalized Contentment Scale.
  • Patients were categorized based on personal or family history of depression.

    • Main Results:

    • Patients with a positive history of depression exhibited significantly higher depression scores.
    • No overall correlation was found between propranolol dosage and depressive symptoms in the entire cohort.
    • A significant positive correlation between propranolol dosage and depression scores was observed specifically in patients with a negative history of depression.

    Conclusions:

    • A history of depression is associated with increased depressive symptoms in patients treated with propranolol for cardiovascular illness.
    • While propranolol dosage did not correlate with depression in the general patient group, it did in those without a prior history, suggesting a potential differential effect.
    • Further research is warranted to elucidate the mechanisms underlying this observed correlation and its clinical implications.