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Updated: Jul 23, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
The trigger for pancreatic disease: NLRP3 inflammasome
Tianming Liu1,2, Qiang Wang1,2, Zhiwei Du1,2
1Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Abstract:
NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a complex regulatory mechanism, and its pro-inflammatory function plays an important role in pancreatic diseases. In this literature review, we summarize the activation mechanism of NLRP3 and analyze its role in each of the four typical pancreatic diseases. Through this article, we provide a relatively comprehensive summary to the researchers in this field, and provide some targeted therapy routes.
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