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Related Experiment Videos

Histological development of intervertebral disc herniation.

T Yasuma, E Makino, S Saito

    The Journal of Bone and Joint Surgery. American Volume
    |September 1, 1986
    PubMed
    Summary

    Degenerative changes in the annulus fibrosus, particularly myxomatous degeneration, are linked to disc herniation. This study identifies a distinct herniation type involving only the annulus fibrosus.

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    Area of Science:

    • Spinal Anatomy
    • Pathology
    • Orthopedic Surgery

    Background:

    • Intervertebral disc herniation is a common condition.
    • The pathomechanism of disc herniation involves the annulus fibrosus and nucleus pulposus.
    • Age-related degenerative changes affect the intervertebral disc structure.

    Purpose of the Study:

    • To investigate the histological changes in the annulus fibrosus and nucleus pulposus in relation to disc herniation.
    • To differentiate between types of disc herniation based on the involved disc components.
    • To explore the role of myxomatous degeneration in the pathogenesis of disc herniation.

    Main Methods:

    • Histological examination of 257 intervertebral discs from autopsies.
    • Histological examination of 441 surgically removed disc herniation samples.
    • Analysis of degenerative changes in the annulus fibrosus and nucleus pulposus.

    Main Results:

    • Myxomatous degeneration of the annulus fibrosus increased with age in autopsy samples.
    • Reversal and degeneration of annulus fibrosus bundles were observed, leading to bulging.
    • Surgically removed herniated disc fragments predominantly showed annulus fibrosus degeneration, not nucleus pulposus involvement.

    Conclusions:

    • A distinct type of disc herniation, termed annulus fibrosus protrusion, exists.
    • This type involves only the annulus fibrosus due to bundle reversal, without nucleus pulposus extrusion.
    • This finding differentiates it from nucleus pulposus herniation through annular fissures.

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