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Postoperative nausea and vomiting after artificial joint replacement surgery: comparison between remimazolam and

Kazuma Yunoki1, Hiroyuki Mima2

  • 1The Department of Anesthesiology and Critical Care, Kobe City Medical Center General Hospital, 2-1-1, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 6500047, Japan. yunokik@kcho.jp.

Journal of Anesthesia
|July 15, 2023
PubMed
Abstract

Insights

Remimazolam and sevoflurane anesthesia show no significant difference in causing postoperative nausea and vomiting (PONV) after joint replacement surgery. This study compared the incidence of PONV between these two anesthetic agents.

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Postoperative nausea and vomiting (PONV) is a common complication following anesthesia.
  • Remimazolam is a novel ultrashort-acting benzodiazepine with potential anesthetic applications.
  • Sevoflurane is a widely used volatile anesthetic agent.

Purpose of the Study:

  • To compare the incidence of postoperative nausea and vomiting (PONV) between remimazolam and sevoflurane.
  • To evaluate anesthetic efficacy for artificial joint replacement surgery.

Main Methods:

  • Retrospective analysis of electronic medical records from 2020-2022.
  • Propensity score matching to control for confounding factors.
  • Comparison of PONV incidence in sevoflurane versus remimazolam anesthesia groups.

Main Results:

  • Initial analysis of 292 patients showed no significant difference in PONV incidence (p=0.461).
  • After propensity score matching (51 patients per group), no significant difference in PONV incidence was observed (p=0.243).
  • Age and ASA-PS differed significantly before matching but were balanced post-matching.

Conclusions:

  • Remimazolam and sevoflurane exhibit comparable safety profiles regarding PONV in patients undergoing artificial joint replacement.
  • Neither anesthetic agent demonstrated a significant advantage in preventing PONV in this patient population.
Keywords:
Postoperative nausea and vomitingPropensity score matchingRemimazolam

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