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Related Experiment Video

Updated: Jul 23, 2025

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
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Benign Glioma.

Peter B Wu1, Anna C Filley2, Michael L Miller3

  • 1Department of Neurosurgery, David Geffen School of Medicine at UCLA, UCLA, Los Angeles, USA.

Advances in Experimental Medicine and Biology
|July 15, 2023
PubMed
Summary
This summary is machine-generated.

Low-grade gliomas (LGG) are slow-growing brain tumors classified as WHO grade I or II. While some are curable with surgery, others transform into malignant tumors, requiring tailored treatment strategies based on molecular features.

Keywords:
Angiocentric gliomaChordoid gliomaDiffuse astrocytomaDiffuse oligodendrogliomaLow-grade gliomaPilocytic astrocytomaPilomyxoid astrocytomaPleomorphic XanthoastrocytomaSubependymal giant cell astrocytomaSubependymoma

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Area of Science:

  • Neuro-oncology
  • Molecular Genetics
  • Tumor Classification

Background:

  • Benign gliomas, also known as low-grade gliomas (LGG), are heterogeneous, slow-growing tumors classified as WHO grade I or II.
  • Advances in molecular genetics have significantly improved the understanding of glioma tumorigenesis and classification.
  • The WHO 2016 classification emphasizes molecular features for accurate glioma diagnosis.

Purpose of the Study:

  • To review the shared and unique features of various benign glioma subtypes.
  • To discuss the diagnostic criteria, treatment strategies, and prognostic implications of LGG.
  • To highlight the evolving understanding of glioma classification and management.

Main Methods:

  • Review of current literature on benign gliomas and low-grade gliomas (LGG).
  • Discussion of diagnostic criteria based on the WHO Classification of Tumors of the Central Nervous System.
  • Analysis of molecular genetics, treatment options (surgery, chemotherapy, radiation therapy), and prognostic factors.

Main Results:

  • Benign gliomas are broadly categorized into focal, well-circumscribed lesions (WHO grade I) and diffuse gliomas (WHO grade II).
  • WHO grade I tumors in pediatric patients often have an excellent prognosis with surgical resection alone.
  • Diffuse gliomas have an infiltrative growth pattern, a propensity for recurrence, and can undergo malignant transformation, necessitating comprehensive management.

Conclusions:

  • The prognosis for benign gliomas varies significantly, with non-infiltrative types generally having an excellent outlook.
  • Maximal safe surgical resection is the primary treatment for both primary and recurrent LGG.
  • Molecular features are crucial for accurate diagnosis, treatment planning, and predicting the prognosis of low-grade gliomas.