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Related Experiment Video

Updated: Jul 23, 2025

Mouse In Vivo Placental Targeted CRISPR Manipulation

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

The human placenta exhibits a unique transcriptomic void.

Sungsam Gong¹, Francesca Gaccioli¹, Irving L M H Aye¹

¹Department of Obstetrics and Gynaecology, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

|July 15, 2023

Summary

This summary is machine-generated.

The human placenta uniquely lacks many transcripts, unlike other organs. This depletion highlights specific placental functions, including mitochondrial and polyamine metabolism.

Keywords:

CP: Developmental biology CP: Molecular biology

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Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants

Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants

Published on: August 31, 2016

Area of Science:

Genomics
Molecular Biology
Human Physiology

Background:

The human placenta has a unique genome with high mutation rates and distinct gene expression.
Understanding tissue-specific gene expression is crucial for deciphering organ function.

Purpose of the Study:

To identify transcripts that are specifically absent or reduced in the human placenta compared to other organs.
To correlate these depleted transcripts with known placental functions.

Main Methods:

Comparative transcriptomic analysis across multiple human organs.
Gene Ontology (GO) analysis to identify enriched pathways within depleted transcript sets.

Main Results:

The placenta exhibits a significant depletion of 762 transcripts, far exceeding other organs like the liver (26 depleted transcripts).
GO analysis revealed enrichment of mitochondrial function genes (e.g., PGC-1α) and polyamine metabolism genes in the placental depleted set.
Depleted transcripts also included those related to neuronal function, consistent with placental physiology.

Conclusions:

The human placenta displays a unique transcriptomic profile characterized by extensive transcript depletion.
This depletion pattern reflects specialized placental functions, particularly in mitochondrial biogenesis and polyamine metabolism.
The findings provide insights into the molecular basis of placental development and function.