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Updated: Jul 23, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.5K

RNA-binding proteins in cellular senescence

Dahyeon Koh1, Hyeong Bin Jeon1, Chaehwan Oh1

  • 1Department of Biological Sciences, Chungnam National University, Daejeon 34134, South Korea.

Mechanisms of Ageing and Development
|July 15, 2023
PubMed

Insights

RNA-binding proteins (RBPs) critically regulate gene expression and cellular senescence. This review summarizes how RBPs influence senescence-associated secretory phenotype, cell cycle, and mitochondrial function.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Cellular senescence is irreversible cell cycle arrest crucial for various biological processes.
  • Regulation of senescence-associated genes is a key molecular event in senescence.
  • RNA-binding proteins (RBPs) are vital post-transcriptional regulators of gene expression.

Purpose of the Study:

  • To summarize the roles of RBPs in cellular senescence.
  • To highlight how RBPs modulate senescence-associated genes.
  • To discuss RBP influence on senescence-associated secretory phenotype, cell cycle, and mitochondrial function.

Main Methods:

  • Literature review of studies on RBPs and cellular senescence.
  • Analysis of RBP mechanisms in regulating gene expression.
  • Focus on RBP impact on key senescence hallmarks.

Main Results:

  • RBPs are critical regulators of cellular senescence.
  • RBPs control senescence through post-transcriptional modifications of target genes.
  • Specific RBPs influence senescence-associated secretory phenotype, cell cycle progression, and mitochondrial integrity.

Conclusions:

  • RBPs play multifaceted roles in orchestrating cellular senescence.
  • Understanding RBP functions in senescence is crucial for therapeutic strategies.
  • Further research into RBPs offers insights into aging and age-related diseases.
Keywords:
Cellular senescencePost-transcriptional regulationRNA-binding proteinSenescence-associated secretory phenotype

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