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Related Experiment Video

Updated: Jul 23, 2025

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

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Heart Transplant Outcomes After Total Artificial Heart.

Francisco A Arabía1, Catherine Friederich Murray2, Ryan Cantor3

  • 1Advanced Heart Program-University Medical Group and University of Arizona College of Medicine-Phoenix, Phoenix, Arizona.

Transplantation Proceedings
|July 15, 2023
PubMed
Summary

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Total artificial heart (TAH) and mechanical circulatory support (MCS) devices like biventricular assist device (BiVAD) and left ventricular assist device (LVAD) are effective bridges to heart transplant (HTX). While survival rates varied, TAH use was associated with higher rates of heart-kidney transplants and post-transplant dialysis.

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Medical Devices

Background:

  • Mechanical circulatory support (MCS) devices, including total artificial heart (TAH), biventricular assist device (BiVAD), and left ventricular assist device (LVAD), are utilized as a bridge to heart transplant (HTX).
  • Data from the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) and the Scientific Registry of Transplant Recipients (SRTR) were used to analyze outcomes.

Purpose of the Study:

  • To compare heart transplant outcomes in patients bridged with TAH versus those bridged with BiVAD or LVAD.
  • To evaluate post-transplant survival and identify risk factors for mortality.

Main Methods:

  • A retrospective analysis of the INTERMACS-SRTR cohort (2006-2015) comparing outcomes of patients receiving TAH, BiVAD, or LVAD prior to HTX.

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Last Updated: Jul 23, 2025

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07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

24.7K
Implantation of the Syncardia Total Artificial Heart
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Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
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  • Primary outcome: posttransplant survival at 1, 36, and 60 months. Secondary outcomes included simultaneous heart-kidney transplants and mortality risk factors.

    • Main Results:

    • Sixty-month post-HTX mortality rates were 15.2% for LVAD, 22.4% for BiVAD, and 29% for TAH.
    • Survival differed between LVAD, TAH, and BiVAD groups, but not between BiVAD and TAH.
    • Higher rates of simultaneous heart-kidney transplants and post-transplant dialysis were observed in the TAH group compared to LVAD and BiVAD groups.

    Conclusions:

    • Total artificial heart (TAH) is an effective bridge to heart transplant (HTX).
    • Potential improvements in TAH outcomes may be achieved through technological advancements and refined patient selection criteria.