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Updated: Jul 23, 2025

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
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Computational modeling multiple conformational states of proteins with residual dipolar coupling data

Hamed Abdollahi1, James H Prestegard2, Homayoun Valafar1

  • 1Department of Computer Science and Engineering, University of South Carolina, 29201, Columbia, SC, USA.

Current Opinion in Structural Biology
|July 16, 2023
PubMed
Summary

Residual dipolar couplings (RDCs) reveal biomolecular motion amplitudes and directions in solution. This technique, enhanced by computational methods like AlphaFold, is crucial for understanding protein dynamics and function.

Keywords:
Conformational changeDynamicNMRProteinResidual Dipolar Coupling

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