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Related Concept Videos

Assessment of the Rectum and Anus01:25

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Related Experiment Video

Updated: Jul 23, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Dichotomous colorectal cancer behaviour.

Sara Aljama1, Estela P Lago1, Olga Zafra1

  • 1Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223 Madrid, Spain.

Critical Reviews in Oncology/Hematology
|July 16, 2023
PubMed
Summary

Colorectal cancer (CRC) exhibits distinct behaviors based on tumor location. Right-sided and left-sided tumors differ in clinical trials, microbiota, and nervous system interactions, impacting treatment strategies.

Keywords:
Clinical trialsColorectal cancerLeft sideMicrobiotaRight side

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Area of Science:

  • Oncology
  • Gastroenterology
  • Microbiome Research

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer mortality.
  • CRC is molecularly heterogeneous, with four Consensus Molecular Subtypes.
  • Anatomical location influences CRC behavior, necessitating further classification.

Purpose of the Study:

  • To review the dichotomic behavior of colorectal cancer based on tumor sidedness.
  • To explore the impact of tumor location on clinical trial data and microbiota.
  • To discuss the interaction between tumor sidedness and the nervous system.

Main Methods:

  • Literature review of current knowledge on right- and left-sided colorectal tumors.
  • Analysis of factors influencing tumor growth, progression, and therapy response.
  • Discussion of spatial tumor heterogeneity and its implications.

Main Results:

  • Colorectal cancer exhibits distinct characteristics based on whether tumors are right-sided or left-sided.
  • Tumor location impacts clinical trial outcomes and gut microbiota composition.
  • Spatial heterogeneity within tumors influences disease progression and treatment efficacy.

Conclusions:

  • Understanding the dichotomy of right- and left-sided colorectal cancer is crucial for personalized treatment.
  • Further research into tumor location-specific factors can improve therapeutic strategies.
  • Investigating the interplay between tumor heterogeneity, microbiota, and the nervous system is key to advancing CRC management.