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Related Experiment Video

Updated: Jul 23, 2025

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Ageing-associated phenotypes in mice.

Kan Xie¹, Dan Ehninger¹

¹Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127 Bonn, Germany.

Mechanisms of Ageing and Development

|July 16, 2023

Summary

This summary is machine-generated.

This review surveys methods for assessing aging phenotypes in mice, a key model organism. It covers physiological, pathological, and molecular changes to guide future aging research.

Keywords:

Ageing Biology Lifespan Mouse Phenotypes

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Last Updated: Jul 23, 2025

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

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Published on: June 18, 2018

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

Area of Science:

Gerontology and aging research.
Comparative biology and animal models.

Background:

Aging is a natural process of progressive damage accumulation leading to decline.
Mice are valuable model organisms for aging research due to physiological similarities to humans.

Approach:

This review surveys current methods and tools for assessing aging phenotypes in mice.
It summarizes age-associated alterations at physiological, pathological, and molecular biomarker levels.

Key Points:

Identifies age-sensitive phenotypes in mice for future studies.
Discusses conceptual and technical challenges in mouse aging research.
Offers recommendations for overcoming research challenges.

Conclusions:

Provides a comprehensive overview of mouse aging assessment.
Aims to inform and improve future studies on organismal aging in mice.