Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Networks02:26

Protein Networks

4.0K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.0K
Protein-protein Interfaces02:04

Protein-protein Interfaces

12.6K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.6K
Proteomics01:33

Proteomics

7.5K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.5K
Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

5.7K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Facilitating NMR Resonance Assignment with Metabolic Tampering.

bioRxiv : the preprint server for biology·2026
Same author

Defining events: 2020 in hindsight.

Science (New York, N.Y.)·2021
Same author

Lamellar cells in Pacinian and Meissner corpuscles are touch sensors.

Science advances·2020
Same author

Novel peptide ligands for antibody purification provide superior clearance of host cell protein impurities.

Journal of chromatography. A·2020
Same author

News from a postpandemic world.

Science (New York, N.Y.)·2020
Same author

Dissociation between Cervical Mucus and Urinary Hormones during the Postpartum Return of Fertility in Breastfeeding Women.

The Linacre quarterly·2020

Related Experiment Video

Updated: Jul 23, 2025

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.2K

Improving protein therapeutic development through cloud-based data integration.

George A Van Den Driessche1, Devin Bailey1, Evan O Anderson2

  • 1Strategic Analytics, Analytical Development, Pharmaceutical Technical Development, Davis Drive, RTP, Biogen, 5000, NC, United States.

SLAS Technology
|July 16, 2023
PubMed
Summary
This summary is machine-generated.

Pharma 4.0 digital transformation leverages Lab Data Capture (LDC) to automate workflows. Implementing LDC with the Tetra Data Platform in quantitative PCR (qPCR) enhances data accessibility and reproducibility.

Keywords:
AutomationCloud platformData harmonizationDigital evolutionLaboratory dataPharma 4.0

More Related Videos

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

131
A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
09:52

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

656

Related Experiment Videos

Last Updated: Jul 23, 2025

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.2K
Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

131
A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
09:52

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

656

Area of Science:

  • Pharmaceutical industry
  • Biotechnology
  • Analytical chemistry

Background:

  • Pharma 4.0 represents a digital shift in the pharmaceutical sector, integrating advanced technologies like AI and cloud computing to modernize scientific workflows.
  • Lab Data Capture (LDC) is crucial for Pharma 4.0, aiming to consolidate and standardize data from disparate laboratory systems.
  • Quantitative PCR (qPCR) workflows generate critical data for biologics development but often involve siloed, file-based outputs.

Purpose of the Study:

  • To describe the implementation of Lab Data Capture (LDC) within a quantitative PCR (qPCR) workflow.
  • To showcase the use of the Tetra Data Platform (TDP) for automating LDC processes.
  • To enable FAIR data practices and a "compliance-by-code" culture in pharmaceutical development labs.

Main Methods:

  • Execution of LDC using the Tetra Data Platform (TDP) on a ViiA7 qPCR instrument.
  • Deployment of file scanning software agents and cloud-based parsing pipelines for data harmonization.
  • Development of web applications for querying, visualizing, and interpreting harmonized qPCR data.

Main Results:

  • Successful aggregation and harmonization of discrete, file-based qPCR data.
  • Automated experiment data processing and process control charting enabled by TDP.
  • Enhanced data findability, accessibility, interoperability, and reproducibility (FAIR) for analytical researchers.

Conclusions:

  • LDC implementation via TDP effectively integrates qPCR data into the Pharma 4.0 initiative.
  • The system facilitates automated data analysis and supports robust process control.
  • This approach promotes FAIR data principles and establishes a "compliance-by-code" framework in development environments.